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DeCS
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Descriptor English:
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Homogentisate 1,2-Dioxygenase
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Descriptor Spanish:
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Homogentisato 1,2-Dioxigenasa
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Descriptor Portuguese:
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Homogentisato 1,2-Dioxigenase
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Synonyms English:
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Homogentisate Dioxygenase
Homogentisate Oxidase
Homogentisate Oxygenase
Homogentisic Acid Oxidase
1,2-Dioxygenase, Homogentisate
Acid Oxidase, Homogentisic
Dioxygenase, Homogentisate
Homogentisate 1,2 Dioxygenase
Oxidase, Homogentisate
Oxidase, Homogentisic Acid
Oxygenase, Homogentisate
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Tree Number:
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D08.811.682.690.416.326
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Definition English:
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A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5. |
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See Related English:
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Alkaptonuria
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History Note English:
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2006(1969)
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Allowable Qualifiers English:
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Record Number:
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50654
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Unique Identifier:
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D050560
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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